M4, Sppressed, Scope, Master Key - MSG 4
The Harbinger - R&C: D
M14EBR, Suppressed - MGS 4
Rail Gun - MGS 4
Boeing Bomb - SWBF2
P90 SD - CoD 4 (Too bad its only on one level).

Anything silent is good, too.

M16 - Call of Duty 4 Multi-Player ( I find burst weapons useful )
MP5 (silenced) - Call of Duty 4 ( For some reason it's one of my best weapons.. )
Berretta(sp?) Sniper Rifle - Call of Duty 4 ( I - LOVE - it )
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Battle Rifle - Halo 3
Assault Rifle - Halo 3
Sniper Rifle - Halo 3
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Auto Shotgun - F.E.A.R 2
Pulse Weapon - F.E.A.R 2 ( You gotta love that thing.. Too bad you only get the weapon twice with 5 shots each.. )
Assault Rifle - F.E.A.R 2
Laser Weapon - F.E.A.R 2
SMG - F.E.A.R 2

Powerd Armor Unit - F.E.A.R 2 ( If it counts, that thing is awesome, Two heavy Machine Guns and missiles )

1. Super Gravity Gun aka Overloaded Gravity Gun - HL2
2. Gravitygun - HL2
3. Portal Gun - Portal (why didn't someone mention it yet!?) (Oh, nvm squipple did ^^)
4. Knife - CombatArms
5. G36C - CombatArms

Grenade Launcher, Forked Sword, Desert Eagle (after stripping Smith of it in the subway level) - The Matrix: Path of Neo
Thermal Detonator - The Phantom Menace (sucky game, awesome explosive)
Symbiote Tentacle - Web of Shadows
Jeep - Tomb Raider The Last Revelation
Flying Sheep - Worms World Party

Please don't bump topics over 30 days old.