Is it possible to create regions where certain weapons fire but others do not? If so, how?

Water is an example. You could try using the Yavin water texture (which is invisible I think) and it would look the same but wouldn't let you fire blasters. That's a possibility.

No, that won't work.

I'll try to explain myself more clearly.

So I have regions A and B, and rifles A and B. I want rifle A to be able to fire in region A, but rifle B not to be able to fire fire in region A. I also want rifle A not to be able to fire in region B, but rifle B can fire in region B.

You make me very curious, what do you want to use this for?
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sorry, I don't really know a way to do that... I don't think it's possible like that....